Article
Exploratory analysis of four polymorphisms in human GGH and FPGS genes and their effect in methotrexate-treated rheumatoid arthritis patients.
Pharmacogenomics - 1 Feb 2007
van der Straaten R J H M, Wessels Judith A M, de Vries-Bouwstra Jeska K, Goekoop-Ruiterman Yvonne P M, Allaart Cornelia F, Bogaartz Judith, Tiller Marco, Huizinga Tom W J, Guchelaar Henk-Jan
Abstract excerpt
The enzyme folylpoly-gamma-glutamase synthethase (FPGS) plays an important role in the intracellular polyglutamation of the disease-modifying antirheumatic drug methotrexate (MTX) and the length of the polyglutamated MTX product correlates with the time that MTX resides in the cell. The glutamates are released from MTX by activity of the enzyme gamma-glutamyl-hydrolase (GGH), thereby allowing the efflux of MTX....
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