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Article

Folylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis.

Scientific reports - 18 Oct 2016

Yamamoto Tatsuhiro, Shikano Kotaro, Nanki Toshihiro, Kawai Shinichi

Abstract excerpt

We investigated major determinants of the intracellular concentrations of methotrexate polyglutamates (MTXPGs) in patients with rheumatoid arthritis (RA). In 271 RA patients on stable oral low dose weekly pulse MTX therapy, the concentrations of MTXPGs in red blood cells (RBCs) were measured by liquid chromatography-electrospray ionization-tandem mass spectrometry. Polymerase chain reaction-restriction fragment...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27752107
DOI: 10.1038/srep35615
PMCID: PMC5067511

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