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Article

Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population.

Biological & pharmaceutical bulletin - 1 Apr 2007

Hayashi Hideki, Fujimaki Chihiro, Inoue Kazuyuki, Suzuki Toshio, Itoh Kunihiko

Abstract excerpt

We investigated the genotype distribution and allele frequency of C452T polymorphism of gamma-glutamyl hydrolase (GGH) gene, which causes the decreased enzymatic activity affecting the efficacy of methotrexate (MTX), in a Japanese population. The polymerase chain reaction-restriction fragment length polymorphism assay was applied to determine the genotype of C452T polymorphism in 269 Japanese healthy individuals....

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Identifiers

PMID: 17409534
DOI: 10.1248/bpb.30.839

Genes

GGH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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