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Article

First detection of plasmid-mediated quinolone resistance (qnrA and qnrS) in Escherichia coli strains isolated from humans in Scandinavia

6 Feb 2007

Abstract excerpt

Sir, Plasmid-mediated quinolone resistance linked to qnr genes (A, B and S) has recently been discovered.1–4 These encode Qnr proteins that are members of the pentapeptide family and are able to protect topoisomerases and thus reduce their susceptibility to fluoroquinolones and increase the mutant selection window, therefore increasing the likelihood of selection of mutations.4,5 Plasmid-mediated fluoroquinolone...

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PMID: 17284539
DOI: 10.1093/jac/dkl554

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