Inverse agonism: from curiosity to accepted dogma, but is it clinically relevant?

Abstract excerpt

Inverse agonism has gone from an initial curiosity to a now well-recognized phenomenon. This has demanded expansion of receptor theory models to account for multiple receptor states and a re-definition of ligand efficacy. However, after several decades of discovery, the clinical importance of inverse agonist ligands is still speculative because this work is founded almost exclusively on artificial systems....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adrenergic beta-Antagonists
• Share to Asthma
• Share to Dose-Response Relationship, Drug