Article
Detection of gene x gene interactions in genome-wide association studies of human population data.
Human heredity - 1 Jan 2007
Musani Solomon K, Shriner Daniel, Liu Nianjun, Feng Rui, Coffey Christopher S, Yi Nengjun, Tiwari Hemant K, Allison David B
Abstract excerpt
Empirical evidence supporting the commonality of gene x gene interactions, coupled with frequent failure to replicate results from previous association studies, has prompted statisticians to develop methods to handle this important subject. Nonparametric methods have generated intense interest because of their capacity to handle high-dimensional data. Genome-wide association analysis of large-scale SNP data is...
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