Article
Role of ASCA and the NOD2/CARD15 mutation Gly908Arg in predicting increased surgical costs in Crohn's disease patients: a project of the European Collaborative Study Group on Inflammatory Bowel Disease.
Inflammatory bowel diseases - 1 Jul 2007
Odes Shmuel, Friger Michael, Vardi Hillel, Claessens Greet, Bossuyt Xavier, Riis Lene, Munkholm Pia, Wolters Frank, Yona Hagit, Hoie Ole, Beltrami Marina, Tsianos Epameinondas, Katsanos Kostas, Mouzas Ioannis, Clofent Juan, Monteiro Estela, Messori Andrea, Politi Patrizia, O'Morain Colm, Limonard Charles, Russel Maurice, Vatn Morten, Moum Bjorn, Stockbrugger Reinhold, Vermeire Severine
Abstract excerpt
BACKGROUND: NOD2/CARD15, the first identified susceptibility gene in Crohn's disease (CD), is associated with ileal stenosis and increased frequency of surgery. Anti-Saccharomyces cerevisiae antibody (ASCA), a serological marker for CD, is associated with ileal location and a high likelihood for surgery. We hypothesized that the presence of ASCA and NOD2/CARD15 mutations could predict increased health care cost...
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