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Article

Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains.

Journal of medicinal chemistry - 1 Nov 2007

Mai Antonello, Artico Marino, Rotili Dante, Tarantino Domenico, Clotet-Codina Imma, Armand-Ugón Mercedes, Ragno Rino, Simeoni Silvia, Sbardella Gianluca, Nawrozkij Maxim B, Samuele Alberta, Maga Giovanni, Esté José A

Abstract excerpt

Following the disclosure of dihydro-alkoxy-, dihydro-alkylthio-, and dihydro-alkylamino-benzyl-oxopyrimidines (DABOs, S-DABOs, and NH-DABOs) as potent and selective anti-HIV-1 agents belonging to the non-nucleoside reverse transcriptase inhibitor (NNRTI) class, we report here the synthesis and biological evaluation of a novel series of DABOs bearing a N,N-disubstituted amino group or a cyclic amine at the...

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Identifiers

PMID: 17910429
DOI: 10.1021/jm070811e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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