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Article

Analysis of mutations in the V3 domain of gp160 that affect fusion and infectivity.

Journal of virology - 1 Jan 1992

Page K A, Stearns S M, Littman D R

Abstract excerpt

The third hypervariable (V3) domain of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein has been proposed to play an important role in mediating viral entry. Antibodies to the V3 domain block HIV-1 infection but not virus binding to CD4. At the center of the V3 domain is a relatively conserved sequence of amino acids, GPGRA. It has previously been shown that mutation of some of these amino...

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Identifiers

PMID: 1727497
DOI: 10.1128/JVI.66.1.524-533.1992
PMCID: PMC238313

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Analysis of mutations in the V3 domain of gp160 that affect fusion and infectivity.PMID 1727497Read ↗

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