Article
Analysis of mutations in the V3 domain of gp160 that affect fusion and infectivity.
Journal of virology - 1 Jan 1992
Page K A, Stearns S M, Littman D R
Abstract excerpt
The third hypervariable (V3) domain of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein has been proposed to play an important role in mediating viral entry. Antibodies to the V3 domain block HIV-1 infection but not virus binding to CD4. At the center of the V3 domain is a relatively conserved sequence of amino acids, GPGRA. It has previously been shown that mutation of some of these amino...
Topics
- Amino Acid Sequence
- CD4 Antigens
- Cell Line
- Gene Products, env
- Giant Cells
- HIV Envelope Protein gp120
- HIV Envelope Protein gp160
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- Peptide Fragments