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Article

Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers.

Molecular cancer - 2 Feb 2007

Hoei-Hansen Christina E, Kraggerud Sigrid M, Abeler Vera M, Kaern Janne, Rajpert-De Meyts Ewa, Lothe Ragnhild A

Abstract excerpt

BACKGROUND: Ovarian germ cell tumours (OGCTs) typically arise in young females and their pathogenesis remains poorly understood. We investigated the origin of malignant OGCTs and underlying molecular events in the development of the various histological subtypes of this neoplasia. RESULTS: We examined in situ expression of stem cell-related (NANOG, OCT-3/4, KIT, AP-2gamma) and germ cell-specific proteins...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17274819
DOI: 10.1186/1476-4598-6-12
PMCID: PMC1797189

Genes

KIT
NANOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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