Article
Heritable clustering and pathway discovery in breast cancer integrating epigenetic and phenotypic data.
BMC bioinformatics - 1 Feb 2007
Wang Zailong, Yan Pearlly, Potter Dustin, Eng Charis, Huang Tim H-M, Lin Shili
Abstract excerpt
BACKGROUND: In order to recapitulate tumor progression pathways using epigenetic data, we developed novel clustering and pathway reconstruction algorithms, collectively referred to as heritable clustering. This approach generates a progression model of altered DNA methylation from tumor tissues diagnosed at different developmental stages. The samples act as surrogates for natural progression in breast cancer and...
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