Article
Familial effects on the clinical course of multiple sclerosis.
Neurology - 30 Jan 2007
Hensiek A E, Seaman S R, Barcellos L F, Oturai A, Eraksoi M, Cocco E, Vecsei L, Stewart G, Dubois B, Bellman-Strobl J, Leone M, Andersen O, Bencsik K, Booth D, Celius E G, Harbo H F, Hauser S L, Heard R, Hillert J, Myhr K-M, Marrosu M G, Oksenberg J R, Rajda C, Sawcer S J, Sørensen P S, Zipp F, Compston D A S
Abstract excerpt
BACKGROUND: Familial factors influence susceptibility to multiple sclerosis (MS) but it is unknown whether there are additional effects on the natural history of the disease. METHOD: We evaluated 1,083 families with > or =2 first-degree relatives with MS for concordance of age at onset, clinical course, and disease severity and investigated transmission patterns of these clinical features in affected parent-child...
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