Article
Variant in the 3' region of the IkappaBalpha gene associated with insulin resistance in Hispanic Americans: The IRAS Family Study.
Obesity (Silver Spring, Md.) - 1 Mar 2010
Miller Melissa R, Zhang Weiming, Sibbel Scott P, Langefeld Carl D, Bowden Donald W, Haffner Steven M, Bergman Richard N, Norris Jill M, Fingerlin Tasha E
Abstract excerpt
The IKKbeta/NF-kappaB pathway is known to play an important role in inflammatory response and has also recently been implicated in the process of insulin resistance. We hypothesized that one or more variants in the IkappaBalpha gene (NFKBIA) or surrounding untranslated regions would be associated with insulin sensitivity (S(I)) in Hispanic-American families. We tested for association between 25 single-nucleotide...
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