Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals.

PLoS genetics - 26 Jan 2007

An Ping, Duggal Priya, Wang Li Hua, O'Brien Stephen J, Donfield Sharyne, Goedert James J, Phair John, Buchbinder Susan, Kirk Gregory D, Winkler Cheryl A

Abstract excerpt

Human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (Apobec3) antiretroviral factors cause hypermutation of proviral DNA leading to degradation or replication-incompetent HIV-1. However, HIV-1 viral infectivity factor (Vif) suppresses Apobec3 activity through the Cullin 5-Elongin B-Elongin C E3 ubiquitin ligase complex. We examined the effect of genetic polymorphisms in the CUL5 gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cullin Proteins

Share to HIV Infections

Share to Longitudinal Studies

Share to Lymphocyte Depletion

Share to Multigene Family

Source

Open in PubMed Open full text

Identifiers

PMID: 17257057
DOI: 10.1371/journal.pgen.0030019
PMCID: PMC1781497

Genes

CUL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals.PMID 17257057Read ↗

HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles.Semantic proximity Read ↗

A single amino acid difference in human APOBEC3H variants determines HIV-1 Vif sensitivity.Semantic proximity Read ↗

CUL5 and APOBEC3G Polymorphisms are Partially Implicated in HIV-1 Infection and Antiretroviral Therapy in a Brazilian Population.Semantic proximity Read ↗

Influence of CCR5 promoter haplotypes on AIDS progression in African-Americans.Semantic proximity Read ↗

Evolutionarily Conserved Requirement for Core Binding Factor Beta in the Assembly of the Human Immunodeficiency Virus/Simian Immunodeficiency Virus Vif-Cullin 5-RING E3 Ubiquitin LigaseSemantic proximity Read ↗

Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex.Semantic proximity Read ↗

Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS.Semantic proximity Read ↗

CCR5 promoter activity correlates with HIV disease progression by regulating CCR5 cell surface expression and CD4 T cell apoptosisSemantic proximity Read ↗

Effect of HIV-1 Vif variability on progression to pediatric AIDS and its association with APOBEC3G and CUL5 polymorphisms.Semantic proximity Read ↗

HECT Domain and RCC1-Like Domain-Containing Protein 5 (HERC-5) Gene Polymorphisms in HIV-1-Infected Individuals: A Study from India.Semantic proximity Read ↗

CCL3L1-CCR5 genotype improves the assessment of AIDS Risk in HIV-1-infected individuals.Semantic proximity Read ↗

CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1-infected individuals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.