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Multiplexed p53 mutation detection by free-solution conjugate microchannel electrophoresis with polyamide drag-tags.

Analytical chemistry - 1 Mar 2007

Meagher Robert J, Coyne Jennifer A, Hestekin Christa N, Chiesl Thomas N, Haynes Russell D, Won Jong-In, Barron Annelise E

Abstract excerpt

We report a new, bioconjugate approach to performing highly multiplexed single-base extension (SBE) assays, which we demonstrate by genotyping a large panel of point mutants in exons 5-9 of the p53 gene. A series of monodisperse polyamide "drag-tags" was created using both chemical and biological synthesis and used to achieve the high-resolution separation of genotyping reaction products by microchannel...

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PMID: 17256875
DOI: 10.1021/ac061903z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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