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A chip-based universal strategy to realize multiplex PCR by using wax films for sealing and controllable release of primers.

Biosensors & bioelectronics - 1 Feb 2025

Li Nan, Zhang Yuanyue, Wang Huili, Xu Xun, Huo Xiaoye, Wang Junbo, Xu Youchun

Abstract excerpt

Simultaneous detection of multiple nucleic acid targets from a single sample is a common requirement in molecular diagnosis and basic research. Dividing a bulky polymerase chain reaction (PCR) into many isolated small reaction units through microfluidic technology is commonly used to realize this goal. However, previous microfluidic platforms for multiplex PCR suffer from complex structures and strict operation...

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PMID: 39550777
DOI: 10.1016/j.bios.2024.116921

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