Article
Allele-specific binding of airway nuclear extracts to polymorphic beta2-adrenergic receptor 5' sequence.
American journal of respiratory cell and molecular biology - 1 Jun 2007
Panebra Alfredo, Schwarb Mary Rose, Glinka Clare B, Liggett Stephen B
Abstract excerpt
Like other intronless G protein-coupled receptor genes, the beta(2)-adrenergic receptor (beta(2)AR) has minimal genetic space for population variability, and has attained such via multiple coding and noncoding polymorphisms. Yet most clinical studies use the two nonsynonymous polymorphisms of the coding region for association analysis despite low levels of linkage disequilibrium with some promoter and 5'UTR...
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