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Article

High-throughput identification of the predominant malaria parasite clone in complex blood stage infections using a multi-SNP molecular haplotyping assay.

The American journal of tropical medicine and hygiene - 1 Jan 2007

Cole-Tobian Jennifer L, Zimmerman Peter A, King Christopher L

Abstract excerpt

Individuals living in malaria endemic areas are often infected with multiple parasite clones. Currently used single nucleotide polymorphism (SNP) genotyping methods for malaria parasites are cumbersome; furthermore, few methods currently exist that can rapidly determine the most abundant clone in these complex infections. Here we describe an oligonucleotide ligation assay (OLA) to distinguish SNPs in the...

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PMID: 17255222
PMCID: PMC3728837

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