Regulatory T-cell phenotype in association with large cell transformation of mycosis fungoides.

Abstract excerpt

INTRODUCTION: Tumor cells of primary cutaneous T-cell lymphomas are able to adopt a regulatory T-cell phenotype in vitro. The significance of this finding in vivo is matter of debate. METHODS: We stained five cases with transformed mycosis fungoides (MF) with an antibody against FOXP3, which is a sensitive and specific marker for the regulatory T-cell phenotype. RESULTS: Transformed T cells in four of five...

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