Transformed Mycosis Fungoides with a Cytotoxic T-Cell Phenotype.

doi:10.1177/10668969221084267

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Article

Transformed Mycosis Fungoides with a Cytotoxic T-Cell Phenotype.

International journal of surgical pathology - 1 Oct 2022

Hiraiwa Shinichiro, Hashimoto Norisato, Ueda Tomoki, Sugiyama Tomoko, Yokoyama Kenji, Matsuyama Takashi, Tajiri Takuma, Nakamura Naoya

Abstract excerpt

Mycosis fungoides (MF) is a cutaneous T-cell lymphoma and occasionally undergo large cell transformation (transformed MF, TMF), resulting in a poorer clinical outcome. We describe a case of TMF with an immunophenotypic shift. MF showed the CD4 + CD8- T-cell phenotype, while TMF exhibited the CD4-CD8 + T-cell phenotype. Moreover, TMF expressed cytotoxic markers of TIA1 and Granzyme B. A PCR analysis of T-cell...

Topics

Cell Transformation, Neoplastic
Humans
Lymphoma, T-Cell, Cutaneous
Mycosis Fungoides
Phenotype
Skin Neoplasms
T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 35253522
DOI: 10.1177/10668969221084267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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