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Infected cell protein No. 22 is subject to proteolytic cleavage by caspases activated by a mutant that induces apoptosis.

Virology - 20 Jan 2003

Munger Joshua, Hagglund Ryan, Roizman Bernard

Abstract excerpt

Earlier reports have shown that the d120 mutant of herpes simplex virus 1 lacking both copies of the gene encoding the infected cells protein No. 4 (ICP4) induces apoptosis in a variety of cell lines. The programmed cell death induced by this mutant is blocked by overexpression of Bcl-2 or by transduction of infected cells with the gene encoding the viral U(S)3 protein kinase. HEp-2 cells infected with the d120...

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Identifiers

PMID: 12573581
DOI: 10.1006/viro.2002.1728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Infected cell protein No. 22 is subject to proteolytic cleavage by caspases activated by a mutant that induces apoptosis.PMID 12573581Read ↗

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