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Article

Nuclear import and retention domains in the amino terminus of RECQL4.

Gene - 15 Apr 2007

Burks Lynnette M, Yin Jinhu, Plon Sharon E

Abstract excerpt

Mutations in a human RecQ helicase homologue, RECQL4, have been identified in patients with Type II Rothmund-Thomson syndrome (RTS) with osteosarcoma predisposition, RAPADILINO syndrome, and Baller-Gerold syndrome. A role in DNA replication initiation has been demonstrated and mapped to the amino terminus upstream of the helicase domain; however, no nuclear localization signal (NLS) has been identified by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17250975
DOI: 10.1016/j.gene.2006.11.019

Genes

RECQL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear import and retention domains in the amino terminus of RECQL4.PMID 17250975Read ↗

RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stressSemantic proximity Read ↗

The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stabilitySemantic proximity Read ↗

Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replication.Semantic proximity Read ↗

Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replicationSemantic proximity Read ↗

RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.Semantic proximity Read ↗

RAPADILINO RECQL4 mutant protein lacks helicase and ATPase activity.Semantic proximity Read ↗

RECQ DNA helicases and osteosarcoma.Semantic proximity Read ↗

Human RecQL4 as a Novel Molecular Target for Cancer Therapy.Semantic proximity Read ↗

Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases.Semantic proximity Read ↗

p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization.Semantic proximity Read ↗

A carboxyl leucine-rich region of parathyroid hormone-related protein is critical for nuclear export.Semantic proximity Read ↗

The involvement of human RECQL4 in DNA double‐strand break repairSemantic proximity Read ↗

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