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Article

p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization.

Journal of cell science - 15 Apr 2009

Dietschy Tobias, Shevelev Igor, Pena-Diaz Javier, Hühn Daniela, Kuenzle Sandra, Mak Raymond, Miah Mohammad Fahad, Hess Daniel, Fey Monika, Hottiger Michael O, Janscak Pavel, Stagljar Igor

Abstract excerpt

RECQL4 belongs to the conserved RecQ family of DNA helicases, members of which play important roles in the maintenance of genome stability in all organisms that have been examined. Although genetic alterations in the RECQL4 gene are reported to be associated with three autosomal recessive disorders (Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes), the molecular role of RECQL4 still remains poorly...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to E1A-Associated p300 Protein

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Share to Nuclear Localization Signals

Share to Protein Processing, Post-Translational

Share to RecQ Helicases

Source

Identifiers

PMID: 19299466
DOI: 10.1242/jcs.037747

Genes

RECQL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization.PMID 19299466Read ↗

The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stabilitySemantic proximity Read ↗

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