Article
The conserved carboxyl terminus of human parainfluenza virus type 2 V protein plays an important role in virus growth.
Virology - 25 May 2007
Nishio Machiko, Tsurudome Masato, Ishihara Hisamitsu, Ito Morihiro, Ito Yasuhiko
Abstract excerpt
Our previous results have shown that some residues of V protein-specific domain in human parainfluenza virus type 2 (hPIV2) are essential not only for STAT protein degradation but also for promoting virus growth. Here, we demonstrated that the virus growth of these recombinant hPIV2s (rPIV2) expressing mutated V proteins were improved in HeLa cell transiently expressing the wild-type V protein, but not in the...
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