Article
Oocyte growth and follicular development in KIT-deficient Fas-knockout mice.
Reproduction (Cambridge, England) - 1 Jan 2007
Moniruzzaman Mohammad, Sakamaki Kazuhiro, Akazawa Yukiko, Miyano Takashi
Abstract excerpt
In mammals, oocyte growth and follicular development are known to be regulated by KIT, a tyrosine kinase receptor. Fas is a member of the death receptor family inducing apoptosis. Here, we investigated germ cell survival, oocyte growth and follicular development in KIT-deficient (Wv/Wv:Fas+/+), Fas-deficient (+/+:Fas-/-), and both KIT- and Fas-deficient (Wv/Wv:Fas-/-) mice during fetal and postnatal periods....
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