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Article

Genetic mechanisms involved in the repression of flagellar assembly by Pseudomonas aeruginosa in human mucus.

Molecular microbiology - 1 Feb 2007

Jyot Jeevan, Sonawane Avinash, Wu Weihui, Ramphal Reuben

Abstract excerpt

Pseudomonas aeruginosa downregulates flagellin transcription when it is grown in purulent mucus from patients with cystic fibrosis (CF) and non-CF bronchiectasis. This response possibly abrogates the potent inflammatory response mediated by the interaction of flagellin with Toll-like receptor 5. The molecular mechanisms involved are thus far unknown. Known flagellar transcriptional regulators were not involved,...

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PMID: 17238927
DOI: 10.1111/j.1365-2958.2006.05573.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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