Article
Response to erlotinib in patients with EGFR mutant advanced non-small cell lung cancers with a squamous or squamous-like component.
Molecular cancer therapeutics - 1 Nov 2012
Paik Paul K, Varghese Anna M, Sima Camelia S, Moreira Andre L, Ladanyi Marc, Kris Mark G, Rekhtman Natasha
Abstract excerpt
We previously reported that although EGFR mutations are not a feature of pure squamous cell carcinomas (SCC) of the lung, these mutations do occur in adenosquamous carcinomas (AD-SCC) and in rare solid adenocarcinomas, both of which can mimic SCC in small samples. Here we present an expanded series of these cases with a focus on sensitivity to erlotinib. The study included 13 patients with EGFR mutant lung...
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