Article
p53 mutation in HCV-genotype-4 associated hepatocellular carcinoma in Egyptian patients.
Journal of the Egyptian National Cancer Institute - 1 Mar 2006
Zekri Abdel Rahman N, Bahnassy Abeer A, Madbouly Maha S, Asaad Nancy Y, El-Shehaby Amal M, Alam El Din Hanaa M
Abstract excerpt
HCV-associated hepatocellular carcinoma (HCC) is a common neoplasm in Egypt where genotype-4 is prevalent. In the present study the incidence and pattern of p53 mutations was assessed in relation to HCV-genotype- 4 in Egyptian HCC patients. We investigated 25 HCV positive HCCs for p53 mutations/overexpression in relation to HCV-NS3 by immunohistochemistry, SSCP and sequencing. Genotyping was done using LiPA-II...
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