Article
Hepatitis B virus-associated hepatocellular carcinoma from India: role of viral genotype and mutations in CTNNB1 (beta-catenin) and TP53 genes.
Journal of gastrointestinal cancer - 1 Mar 2011
Vivekanandan Perumal, Torbenson Michael, Ramakrishna Banumathi
Abstract excerpt
PURPOSE: Chronic hepatitis B virus (HBV) infection is the major risk factor for hepatocellular carcinoma (HCC) in India. Studies from other countries have linked HBV genotype C to a higher risk for HCC. This study was carried out to determine the association between genotype and HCC and also the frequency of mutations in CTNNB1 (beta-catenin) and TP53 genes in HBV-related HCC. METHODS: Formalin-fixed...
Topics
- Adult
- Aged
- Autopsy
- Carcinoma, Hepatocellular
- DNA, Viral
- Exons
- Female
- Genotype
- Hepatitis B
- Hepatitis B virus
- Humans
- India
- Liver Neoplasms
- Male
- Middle Aged