Article
Presence of genes encoding panton-valentine leukocidin is not the primary determinant of outcome in patients with hospital-acquired pneumonia due to Staphylococcus aureus.
Journal of clinical microbiology - 1 Mar 2012
Sharma-Kuinkel Batu K, Ahn Sun H, Rude Thomas H, Zhang Yurong, Tong Steven Y C, Ruffin Felicia, Genter Fredric C, Braughton Kevin R, Deleo Frank R, Barriere Steven L, Fowler Vance G
Abstract excerpt
The impact of Panton-Valentine leukocidin (PVL) on the outcome in Staphylococcus aureus pneumonia is controversial. We genotyped S. aureus isolates from patients with hospital-acquired pneumonia (HAP) enrolled in two registrational multinational clinical trials for the genetic elements carrying pvl and 30 other virulence genes. A total of 287 isolates (173 methicillin-resistant S. aureus [MRSA] and 114...
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