Evidence for a molecular link between the tuberous sclerosis complex and the Crumbs complex

Abstract excerpt

In human, mutations in tuberous sclerosis complex protein 1 or 2 (TSC1/2 or hamartin/tuberin) cause tuberous sclerosis characterized by the occurrence of multiple hamartomas. On the other hand, mutations in the Crumbs homolog-1 (CRB1) gene cause retinal degeneration diseases including Leber congenital amaurosis and retinitis pigmentosa type 12. Here we report, using a two-hybrid assay, a direct molecular...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hedgehog Signaling Pathway Studies
• Share to Hippo pathway signaling and YAP/TAZ
• Share to Tuberous Sclerosis Complex Research