Article
TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions.
Experimental and molecular pathology - 1 Aug 2007
Sirotkovic-Skerlev Maja, Cacev Tamara, Krizanac Simun, Kulić Ana, Pavelic Kresimir, Kapitanovic Sanja
Abstract excerpt
Polymorphisms in genes involved in the complex mechanisms of carcinogenesis may affect the susceptibility to cancer. The multifunctional cytokine tumor necrosis factor alpha (TNF alpha) has an important role in the pathogenesis of inflammatory, autoimmune and malignant diseases. It has a large spectrum of activities, including both antitumorigenic and protumorigenic. In recent years, several TNF alpha promoter...
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