Enrichment and characterization of uncommitted B-cell precursors from fetal liver at day 12 of gestation.

doi:10.1002/j.1460-2075.1992.tb05091.x

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Article

Enrichment and characterization of uncommitted B-cell precursors from fetal liver at day 12 of gestation.

The EMBO journal - 1 Feb 1992

Cumano A, Paige C J

Abstract excerpt

We describe an assay system that allows precursor cells, uncommitted for heavy and light chain immunoglobulin expression, to develop into B lymphocytes that can differentiate to antibody-producing cells. Some precursors have the immunoglobulin loci in germ-line configuration. Approximately 200-15...

Topics

Animals
Antibody Formation
Antigens, Surface
B-Lymphocytes
Cell Differentiation
Cells, Cultured
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique
Gestational Age
Immunoglobulin Allotypes
Immunoglobulin Heavy Chains
Immunoglobulin Isotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Light Chains

Immunoglobulins

Liver

Lymphocyte Activation

Mice

Mice, Inbred BALB C

Source

Open in PubMed Open full text

Identifiers

PMID: 1537338
DOI: 10.1002/j.1460-2075.1992.tb05091.x
PMCID: PMC556491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1537338-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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