Analysis of the newly identified neutralization epitopes on VP7 of human rotavirus serotype 1.

doi:10.1099/0022-1317-72-1-117

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Article

Analysis of the newly identified neutralization epitopes on VP7 of human rotavirus serotype 1.

The Journal of general virology - 1 Jan 1991

Kobayashi N, Taniguchi K, Urasawa S

Abstract excerpt

Neutralizing monoclonal antibodies (MAbs) directed to the VP7 protein and neutralization-resistant mutants were used to analyse the antigenic structure of VP7 of human rotavirus serotype 1. Cross-neutralization tests using the MAbs and the resistant mutants indicated the existence of two functionally independent neutralization epitope regions (S1 and S2) on VP7. Region S1 corresponds to a single epitope domain of...

Topics

Animals
Antibodies, Monoclonal
Antigens, Viral
Capsid
Capsid Proteins
Cell Line
Cloning, Molecular
Codon
Enzyme-Linked Immunosorbent Assay
Epitopes
Genes, Viral
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred BALB C

Mutation

Neutralization Tests

Rotavirus

Serotyping

Source

Open in PubMed

Identifiers

PMID: 1703558
DOI: 10.1099/0022-1317-72-1-117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1703558-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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