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SRC-p300 Coactivator Complex Is Required for Thyroid Hormone-induced Amphibian Metamorphosis

12 Jan 2007

Abstract excerpt

Gene activation by the thyroid hormone (T3) receptor (TR) involves the recruitment of specific coactivator complexes to T3-responsive promoters. A large number of coactivators for TR have been isolated and characterized in vitro. However, their roles and functions in vivo during development have remained largely unknown. We have utilized metamorphosis in Xenopus laevis to study the role of these coactivators...

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PMID: 17218308
DOI: 10.1074/jbc.m607589200

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