Article
Thyroid hormone receptor actions on transcription in amphibia: The roles of histone modification and chromatin disruption
1 Jan 2012
Abstract excerpt
Thyroid hormone (T3) plays diverse roles in adult organ function and during vertebrate development. The most important stage of mammalian development affected by T3 is the perinatal period when plasma T3 level peaks. Amphibian metamorphosis resembles this mammalian postembryonic period and is absolutely dependent on T3. The ability to easily manipulate this process makes it an ideal model to study the molecular...
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