Article
Allelic variants in HOX genes in cryptorchidism.
Birth defects research. Part A, Clinical and molecular teratology - 1 Apr 2007
Wang Yanping, Barthold Julia, Kanetsky Peter A, Casalunovo Tracy, Pearson Erin, Manson Jeanne
Abstract excerpt
BACKGROUND: Cryptorchidism is one of the most common congenital anomalies and is associated with increased risk for infertility and testicular cancer later in life. Findings from animal models and small clinical studies suggest that the posterior HOX genes (paralogs 9-13) could be potential candidate genes for cryptorchidism and that the HOX genes are functionally redundant within paralogous groups. METHODS: The...
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