Article
Analysis of homeobox gene HOXA10 mutations in cryptorchidism.
The Journal of urology - 1 Jan 1999
Kolon T F, Wiener J S, Lewitton M, Roth D R, Gonzales E T, Lamb D J
Abstract excerpt
PURPOSE: Cryptorchidism is the most common congenital abnormality of the genitalia. However, its exact etiology remains to be defined. Homeobox (HOX) containing genes have a key role in the morphogenesis of segmental structures along the primary body axis, including the urogenital mesenchyma. In male mice with a targeted deletion of the HOXA10 gene cryptorchidism manifests in the absence of other major defects....
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