Impaired respiration is positively correlated with decreased life span in <i>Caenorhabditis elegans</i> models of Friedreich Ataxia

Abstract excerpt

Impaired expression of mitochondrial genes causes alterations in life span of the nematode Caenorhabditis elegans. Intriguingly, although some of these genes have been shown to extend life expectancy and reduce aging processes, others are known to shorten life span in the same model organism. Reduced expression of a mitochondrial protein called frataxin causes a neurodegenerative disorder named Friedreich Ataxia,...

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