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Article

Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families.

Archives of neurology - 1 Jan 2007

Mesulam Marsel, Johnson Nancy, Krefft Thomas A, Gass Jennifer M, Cannon Ashley D, Adamson Jennifer L, Bigio Eileen H, Weintraub Sandra, Dickson Dennis W, Hutton Michael L, Graff-Radford Neill R

Abstract excerpt

BACKGROUND: Primary progressive aphasia (PPA) is a language-based dementia characterized by fluent or nonfluent language disorder as its principal feature. OBJECTIVE: To describe progranulin gene mutations in 2 families with PPA. DESIGN: Report of affected families. SETTING: Academic research. PATIENTS: Two families, PPA1 and PPA3, were studied. Genomic DNA was isolated from 3 of 4 siblings in PPA1, from all 3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17210807
DOI: 10.1001/archneur.64.1.43

Genes

PPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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