Article
Familial primary progressive aphasia.
Alzheimer disease and associated disorders - 1 Jan 2000
Krefft Thomas A, Graff-Radford Neill R, Dickson Dennis W, Baker Matt, Castellani Rudy J
Abstract excerpt
Primary progressive aphasia (PPA) is a neurodegenerative disease presenting with isolated, progressive, language dysfunction. After at least 2 years, dementia may develop, but the aphasia predominates. Few families with hereditary PPA have been reported; some have autosomal dominance. A chromosome 17 mutation in tau exon 13 has been found in one family, and a few have linkage to chromosome 17. However, early...
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