Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanisms of Mitotic Cell Death Induced by Chemotherapy-Mediated G2 Checkpoint Abrogation

1 Jan 2007

Abstract excerpt

The novel concept of anticancer treatment termed "G(2) checkpoint abrogation" aims to target p53-deficient tumor cells and is currently explored in clinical trials. The anticancer drug UCN-01 is used to abrogate a DNA damage-induced G(2) cell cycle arrest leading to mitotic entry and subsequent cell death, which is poorly defined as "mitotic cell death" or "mitotic catastrophe." We show here that UCN-01 treatment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17210716
DOI: 10.1158/0008-5472.can-06-2548

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanisms of Mitotic Cell Death Induced by Chemotherapy-Mediated G2 Checkpoint AbrogationPMID 17210716Read ↗

Mitotic slippage: an old tale with a new twistSemantic proximity Read ↗

Mitotic checkpoint defects in human cancers and their implications to chemotherapySemantic proximity Read ↗

Spindle Poisons and Cell Fate: A Tale of Two PathwaysSemantic proximity Read ↗

Cell cycle checkpoints and their impact on anticancer therapeutic strategiesSemantic proximity Read ↗

Anticancer drug targets: cell cycle and checkpoint controlSemantic proximity Read ↗

Mitotic syndicates Aurora Kinase B (AURKB) and mitotic arrest deficient 2 like 2 (MAD2L2) in cohorts of DNA damage response (DDR) and tumorigenesisSemantic proximity Read ↗

[Molecular mechanism of cell death induced by chemotherapeutic agents].Semantic proximity Read ↗

Mapping Mitotic Death: Functional Integration of Mitochondria, Spindle Assembly Checkpoint and ApoptosisSemantic proximity Read ↗

Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic deathSemantic proximity Read ↗

Mitosis-targeted anti-cancer therapies: where they standSemantic proximity Read ↗

Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly.Semantic proximity Read ↗

Antiproliferative Fate of the Tetraploid Formed after Mitotic Slippage and Its Promotion; A Novel Target for Cancer Therapy Based on Microtubule PoisonsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.