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Article

Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.

Neuroscience research - 1 Mar 2007

Shimojo Masafumi, Sahara Naruhiko, Murayama Miyuki, Ichinose Hiroshi, Takashima Akihiko

Abstract excerpt

Presenilin (PS) is a catalytic subunit of the gamma-secretase complex that cleaves the intramembranous region of amyloid precursor protein (APP), producing amyloid beta (Abeta) peptide. Familial Alzheimer's disease (FAD) results from PS mutations, which may alter gamma-secretase activity to enhance the production of highly aggregable Abeta42. The precise pathogenic effects of mutant PS remain unclear. To exclude...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17210196
DOI: 10.1016/j.neures.2006.12.005

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.PMID 17210196Read ↗

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