Article
Mtf-1 lymphoma-susceptibility locus affects retention of large thymocytes with high ROS levels in mice after gamma-irradiation.
Biochemical and biophysical research communications - 2 Mar 2007
Maruyama Masaki, Yamamoto Takashi, Kohara Yuki, Katsuragi Yoshinori, Mishima Yukio, Aoyagi Yutaka, Kominami Ryo
Abstract excerpt
Mouse strains exhibit different susceptibilities to gamma-ray-induced thymic lymphomas. Our previous study identified Mtf-1 (metal responsive transcription factor-1) as a candidate susceptibility gene, which is involved in the radiation-induced signaling pathway that regulates the cellular reactive oxygen species (ROS). To reveal the mechanism for the increased susceptibility conferred by Mtf-1 locus, we examined...
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