Article
Genes required for glycolipid synthesis and lipoteichoic acid anchoring in Staphylococcus aureus.
Journal of bacteriology - 1 Mar 2007
Gründling Angelika, Schneewind Olaf
Abstract excerpt
Staphylococcus aureus lipoteichoic acid (LTA) is composed of a linear 1,3-linked polyglycerolphosphate chain and is tethered to the bacterial membrane by a glycolipid (diglucosyl-diacylglycerol [Glc2-DAG]). Glc2-DAG is synthesized in the bacterial cytoplasm by YpfP, a processive enzyme that transfers glucose to diacylglycerol (DAG), using UDP-glucose as its substrate. Here we present evidence that the S. aureus...
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