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Article

Cystic fibrosis risk variants confer protection against inflammatory bowel disease.

Cell genomics - 11 Feb 2026

Yu Mingrui, Zhang Qian, Yuan Kai, Sazonovs Aleksejs, Stevens Christine R, Fachal Laura, Lamb Christopher A, Anderson Carl A, Daly Mark J, Huang Hailiang

Abstract excerpt

Genetic mutations that yield a defective cystic fibrosis (CF) transmembrane regulator (CFTR) protein cause CF, a life-limiting autosomal-recessive Mendelian disorder. A protective role of CFTR loss-of-function mutations in inflammatory bowel disease (IBD) has been suggested, but its evidence has been inconclusive and contradictory. Here, leveraging a large IBD exome sequencing dataset comprising 38,558 cases and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41330381
DOI: 10.1016/j.xgen.2025.101071
PMCID: PMC12903406

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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