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Article

CA/GT microsatellite alleles within the cystic fibrosis transmembrane conductance regulator (CFTR) gene are not generated by unequal crossingover.

Genomics - 1 Jul 1991

Morral N, Nunes V, Casals T, Estivill X

Abstract excerpt

The gene responsible for cystic fibrosis (CF) has recently been identified, and a three-nucleotide deletion (delta F508 mutation) that results in the loss of a phenylalanine residue in the first putative ATP-binding domain of the predicted protein (CF transmembrane conductance regulator, CFTR) has been found to be the major CF mutation. Although several other mutations have been identified in the CFTR gene, most...

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Source

Identifiers

PMID: 1716244
DOI: 10.1016/0888-7543(91)90454-m

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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CA/GT microsatellite alleles within the cystic fibrosis transmembrane conductance regulator (CFTR) gene are not generated by unequal crossingover.PMID 1716244Read ↗

A dimorphic 4-bp repeat in the cystic fibrosis gene is in absolute linkage disequilibrium with the delta F508 mutation: implications for prenatal diagnosis and mutation origin.Semantic proximity Read ↗

Uniparental inheritance of microsatellite alleles of the cystic fibrosis gene (CFTR): identification of a 50 kilobase deletion.Semantic proximity Read ↗

Deep resequencing of CFTR in 762 F508del homozygotes reveals clusters of non-coding variants associated with cystic fibrosis disease traitsSemantic proximity Read ↗

A variable dinucleotide repeat in the CFTR gene contributes to phenotype diversity by forming RNA secondary structures that alter splicing.Semantic proximity Read ↗

Short direct repeats at the breakpoints of a novel large deletion in the CFTR gene suggest a likely slipped mispairing mechanism.Semantic proximity Read ↗

A CA repeat in the first intron of the CFTR gene.Semantic proximity Read ↗

Exon 9 of the CFTR gene: splice site haplotypes and cystic fibrosis mutations.Semantic proximity Read ↗

Analysis of CA/GT microsatellite polymorphism in IVS8 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene: a study of Italian CF families.Semantic proximity Read ↗

CFTR haplotypic variability for normal and mutant genes in cystic fibrosis families from southern France.Semantic proximity Read ↗

Genomic rearrangements in the CFTR gene: extensive allelic heterogeneity and diverse mutational mechanisms.Semantic proximity Read ↗

A cluster of highly polymorphic dinucleotide repeats in intron 17b of the cystic fibrosis transmembrane conductance regulator (CFTR) gene.Semantic proximity Read ↗

Microsatellite haplotypes for cystic fibrosis: mutation frameworks and evolutionary tracers.Semantic proximity Read ↗

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