Article
CA/GT microsatellite alleles within the cystic fibrosis transmembrane conductance regulator (CFTR) gene are not generated by unequal crossingover.
Genomics - 1 Jul 1991
Morral N, Nunes V, Casals T, Estivill X
Abstract excerpt
The gene responsible for cystic fibrosis (CF) has recently been identified, and a three-nucleotide deletion (delta F508 mutation) that results in the loss of a phenylalanine residue in the first putative ATP-binding domain of the predicted protein (CF transmembrane conductance regulator, CFTR) ha...
Topics
- Alleles
- Base Composition
- Base Sequence
- Chromosome Deletion
- Crossing Over, Genetic
- Cystic Fibrosis Transmembrane Conductance Regulator
- DNA Mutational Analysis
- DNA, Satellite
- Exons
- Genes
- Haplotypes
- Humans
- Membrane Proteins
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Recombination, Genetic