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Article

Identification of Genes Selectively Regulated by IFNs in Endothelial Cells

1 Jan 2007

Abstract excerpt

IFNs are highly pleiotropic cytokines also endowed with marked antiangiogenic activity. In this study, the mRNA expression profiles of endothelial cells (EC) exposed in vitro to IFN-alpha, IFN-beta, or IFN-gamma were determined. We found that in HUVEC as well as in other EC types 175 genes were up-regulated (>2-fold increase) by IFNs, including genes involved in the host response to RNA viruses, inflammation, and...

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PMID: 17202376
DOI: 10.4049/jimmunol.178.2.1122

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