Article
Structural role of tyrosine 98 in photoactive yellow protein: effects on fluorescence, gateway, and photocycle recovery.
Biochemistry - 9 Jan 2007
Kyndt John A, Savvides Savvas N, Memmi Samy, Koh Moonjoo, Fitch John C, Meyer Terry E, Heyn Maarten P, Van Beeumen Jozef J, Cusanovich Michael A
Abstract excerpt
We have recently shown that the Y98Q mutant of PYP has a major effect on the photocycle kinetics ( approximately 40 times slower recovery). We have now determined the crystal structure of Y98Q at 2.2 A resolution to reveal the role of residue Y98 in the PYP photocycle. Although the overall structure is very similar to that of WT, we observed two major effects of the mutation. One obvious consequence is a...
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