Article
Investigation of de novo totally random biosequences, Part II: On the folding frequency in a totally random library of de novo proteins obtained by phage display.
Chemistry & biodiversity - 1 Aug 2006
Chiarabelli Cristiano, Vrijbloed Jan W, De Lucrezia Davide, Thomas Richard M, Stano Pasquale, Polticelli Fabio, Ottone Tiziana, Papa Ester, Luisi Pier Luigi
Abstract excerpt
We present an investigation on theoretically possible protein structures which have not been selected by evolution and are, therefore, not present on our Earth ('Never Born Proteins' (NBP)). In particular, we attempt to assess whether and to what extent such polypeptides might be folded, thus acquiring a globular protein status. A library (ca. 10(9) clones) of totally random polypeptides, with a length of 50...
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